Endocrine Abstracts

Background: O-6-Methylguanine-DNA-methyltransferase (MGMT) is a DNA repair enzyme. It has been demonstrated that its higher expression counteracts cytotoxicity of alkylating agents used in the treatment of glioblastoma or invasive pituitary tumors. Little is known on the relationships between MGMT expression and invasiveness of corticotroph adenomas in Cushing disease (CD).The Aim: To evaluate MGMT expression and its associations with clinical, neuropath...